Locate the downloaded .exe file and double-click it.

Click Run on the Security Warning

Click Yes on UAC

Activation

Alternatively you an run the slim / portable version of CCleaner.
Download the .zip file and navigate to the location of the file.

Right click the file > Extract All...

Wait for the extraction to finish

Open the folder and double click the CCleaner64.exe file

Click Run on the Security Warning popup

Click Yes on the UAC screen

This is the CCleaner Free version we need to add the activation key to upgrade it to the full version

Wait for the software to update

SKU: 6719, 6720, 6721, 6722, 6727, 6723, 6724, 6725, 6726